A TRIP to Remember! by Anabela Relvas

When I first joined TRIP, I had no idea how much I would grow as a scientist, a problem-solver, and a communicator. Over the past few months, I’ve been actively involved in research, learned how to design and troubleshoot experiments, and figured out how to push through setbacks and challenges that come with scientific work. For my independent experiment, I decided to explore how early-life stress affects memory affects memory in teenagers, and whether or not Vitamin D3 may be able to improve memory. The rationale behind this question comes from my interest in how early stressors, such as childhood trauma, can affect cognitive function, especially in teenagers who are dealing with the aftermath of early-life stress while navigating the challenges of adolescence. If we understand these effects better, we might find ways to support cognitive development and emotional well-being in teenagers struggling with trauma and stress from their childhood.  

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So, what did I find? UV exposure significantly impaired memory in larvae, which supports the idea that early-life stress can lead to long-term cognitive consequences. This is especially important for understanding how trauma, even at early stages, can affect memory and potentially influence learning and memory abilities later in teenagers. I also found that Vitamin D3 helped partially improve the memory loss caused by UV exposure, and even slightly improved memory in unstressed flies. While it’s not a cure-all, this suggests that Vitamin D3 could offer some neuroprotective benefits and possibly provide a small but meaningful boost for individuals recovering from early trauma. Looking ahead, further research could help determine the best dose of Vitamin D3 for improving memory, and it would be really interesting to see if long-term use could not only improve memory but possibly even reverse some of the permanent effects of early-life stress. This could be a step toward finding real solutions to help those who have experienced early-life stress and trauma. 

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One of the most rewarding parts of TRIP was designing my own experiment from scratch. It was both exciting and overwhelming to have that level of freedom and responsibility. There were definitely moments when things didn’t go as planned: vials got mixed up, flies randomly disappeared, and protocols had to be adjusted. But each challenge taught me something new, and I became more confident each week. I also loved getting to know my fellow TRIPmates. Everyone brought their own unique ideas and perspectives, and the community we built together was one of the best parts of the experience.

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Looking back, I’m incredibly grateful for the opportunity to be part of TRIP. I’ve learned how to ask meaningful scientific questions, troubleshoot experiments, analyze data, and present my findings to others. These skills will stay with me as I move forward in every aspect of my life no matter where I end up. TRIP has shown me the power of curiosity, persistence, and teamwork. To anyone thinking about applying to TRIP: do it. You’ll work hard, learn a lot, and come away with an unforgettable experience.

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